Body Composition and Weight Management
You have to do something different to get different results. Follow a formal diet plan. Weight watchers, quick weight loss centers have helped just about every patient we have sent. What you are doing now is not working...is it? Dr. Rabin prefers programs where you make your own food.
The new Enhanced Irvingia
formula provides a combination of nutrients that combat
age-related fat accumulation via the following seven
distinct mechanisms:
- Enhancing resting energy expenditure at the cellular
level.
- Slowing the absorption of dietary fat from the
intestines.
- Moderating alpha-amylase enzyme activity to reduce
the absorption of carbohydrates into the bloodstream
- Reducing alpha-glucosidase enzyme activity to
further slow the absorption of starches and sugars into
the bloodstream.
- Supporting leptin sensitivity to reduce hunger and
stimulate lipolysis
- Supporting youthful levels of adiponectin to help
maintain healthy insulin sensitivity
- Moderating glycerol-3-phosphate dehydrogenase enzyme
activity to reduce the amount of ingested starches that
are converted to triglycerides and stored as fat.
Leptin sensitivity
Fat cells (adipocytes) secrete a hormone called leptin
that tells our brain when we have eaten enough. Leptin can
also facilitate the breakdown of stored triglycerides in our
adipocytes via the process of lipolysis. Heavy individuals
have startlingly high blood levels of leptin, indicating
that their cells have become resistant to the leptin that is
supposed to prevent them from putting on so many pounds of
fat.
An extract from a West African food called Irvingia
gabonensis has been shown to help support leptin
sensitivity in overweight people. In a recently published
study, Irvingia demonstrated beneficial effects upon leptin
blood levels, followed by weight loss and a reduction in
waist circumference.3 In addition to supporting healthy leptin sensitivity,
Irvingia has demonstrated the following beneficial effects
on key aspects of metabolism:
Glyercol-3-phosphate dehydrogenase is an enzyme involved
in the complex biochemical process that converts ingested
starch and sugar calories to stored body fat. Irvingia has
been shown in studies involving fat cells to reduce the
activity of glycerol-3-phosphate dehydrogenase4, which may
help reduce the impact of starch and sugar calories on body
fat.
Scientific research on fat cells suggests that Irvingia
has alpha-amylase-inhibiting properties5 (like InSea2™
and Phaseolus vulgaris) which can help support a
slowing of the rate of carbohydrate absorption from the
intestines and a reduction of the caloric impact of starchy
and sugary foods.
Adiponectin is a hormone involved in helping to maintain
insulin sensitivity on the membranes of energy-producing
cells. Large fat cells produce less adiponectin, and
overweight people need to be especially concerned about
maintaining healthy levels of adiponectin to support insulin
sensitivity and metabolic fitness. Scientific data suggests
that Irvingia helps support healthy adiponectin levels.
References
1. Integr Nutr. 2008;11(2):1-14.
2. Int J Med Sci. 2007;4:45-52.
3. Lipids Health Dis. 2009 Mar 2;8:7
4. Lipids Health Dis. 2008 Nov 13;7:44
5. Ann Nutr Metab. 1993;37(1):14-23.
This supplement should be taken 15 minutes before your 2
biggest meals in conjunction with a
healthy diet and regular exercise program. Results may vary.
 Go to the Weight Loss category at
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 This
Fiber, when taken before each meal, can help your dieting
efforts by helping you feel full sooner, and by slowing the
absorption of sugars and cholesterol. Read about how
this works:
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The Science of PGX
More than a decade of
research has gone into the development of PGX. While the
intricate hormonal, molecular and cellular details of how it
works may be complex, the basic principles that make this
product effective are very simple. Volume and viscosity are
key.
Proprietary Composition
The method in which soluble fibres are made into
PolyGlycopleX� (PGX�) is a proprietary
process known as EnviroSimplex�. Each capsule,
granule or powdered product contains the exact balanced
ratio of components. All manufacturing, processing and
packaging steps meet or exceed government and industry
standards and all Good Manufacturing Practices are adhered
to. The PGX� composition is patent protected and
is composed of unique polysaccharides that complement each
other and act synergistically to form strong molecular bonds
for extremely high viscosity, 3-5 times higher than any
single known polysaccharide. As mentioned, the physiological
effects and overall benefits to human health of a soluble
fibre are directly proportionate to its viscosity.
In PGX, because the right soluble polysaccharides are
combined, they act synergistically to create a stable gel
"matrix" that can suspend ingested liquid and nutrients for
digestion. When PGX is mixed with food in the gut, the
matrix slows digestion and extends the area for nutrient
absorption through the stomach and the small intestine.
PGX's capacity to capture and suspend nutrients (such as
sugars, fat and carbohydrates) is key to its physiological
benefits, especially after meal glucose-lowering, as
demonstrated in clinical trials.
Slow Viscosity
The viscosity of PGX� develops slowly after
mixing with water, with maximum viscosity reached after 60
to 90 minutes. When using PGX meal replacement shakes or
granules, this means that it remains palatable when
prepared, and develops its full viscosity in the stomach and
small intestine. Unlike many other fibres, PGX maintains its
highly viscous properties in spite of the influence of
stomach acid and digestive enzymes.
Optimum Volume
Studies have shown that the volume from food creates a sense
of fullness in the stomach. This sense of fullness triggers
the release of various signaling hormones that alert the
brain to stop eating. When PGX� is taken before a
meal or in a meal replacement, a sense of fullness and
satiety quickly develops. PGX studies have shown that the
ingestion of PGX quickly affects these signaling hormones in
people with diseases related to blood sugar. In the
intestine, PGX remains highly volumetric and viscous,
delaying in the return of hunger pangs.
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Research Results
A randomized, double-blind, placebo controlled trial
investigated the effects of 5 grams of a low-viscosity fibre,
5 grams of a medium-viscosity fibre, and 5 grams of PGX� added to meal replacement drinks for 31 healthy individuals.
Ninety minutes after taking the fibre-enhanced drinks,
participants were given pizza to consume as much as they
wanted. The amount eaten was used as an objective measure of
appetite suppression. Those who drank the PGX-based meal
replacement consumed the least amount of pizza compared to
those who had the low and medium viscosity drinks. Even
though the PGX group consumed less, they did not compensate
at their next meal1.
The effects of PGX as a weight loss aid were also assessed
in two weight loss programs conducted at the Canadian Center
for Functional Medicine in British Columbia. In each program
participants received basic instructions for caloric
reduction and exercise, and consumed 5 grams of PGX two to
three times per day. One program looked at the effect of PGX
on weight loss over a 14 week period in sedentary,
overweight or obese adults. There was a significant
reduction in average weight (-13.0 pounds), waist
circumference (-5.0 inches), and percent body fat (-2.5%).
Moreover, these changes were paralleled by a significant
decrease in total cholesterol (-18.0%), LDL (-25.0%),
fasting glucose (-7.0%) and insulin (-26.0%) levels over a
time span of 14 weeks2. Body composition
measurements showed most subjects lost body fat with little
change to their lean muscle mass and body water.
The second program used a meal replacement with PGX and PGX
granules on weight loss in overweight and obese adults over
a 10 week period. From the patients who participated, there
was an average reduction in weight of 11 pounds and waist
circumference of 2.5 inches. Most subjects reported that the
meal replacement drink created a sense of satiety and
completely controlled their hunger for 3-4 hours.
Patients in the weight management group were connected to a
Continuous Blood Glucose Monitoring System (CGMS). Results
show that those with weight challenges have wide and
frequent swings in blood glucose levels. Most overweight and
obese subjects had high glycemic volatility at baseline and
markedly diminished glycemic volatility after using PGX3.
Glycemic Index
The effect of PGX� on appetite and satiety
has been demonstrated in double-blind placebo-controlled
trials. In a study presented at the American Diabetes
Association Conference in 2006, a three-week program of PGX
produced a fifty percent reduction in after-meal insulin
levels and a forty percent improvement in insulin
sensitivity for participants, along with a significant
decrease in after-meal blood sugars.
At the Glycemic Index Laboratories in Toronto, researchers
found that when PGX was added to foods or beverages it
greatly reduced their glycemic index. This means that any
food taken with PGX can have a substantially lower glycemic
impact, and glycemic volatility is reduced within days by
taking PGX.
Studies on PGX have shown reduced risk factors associated
with the Metabolic Syndrome by:
-
reducing waist circumference and
intra-abdominal fat4,5
-
lowering after-meal and fasting
blood sugar levels3,4,6
-
lowering cholesterol6,7;
and
-
improving insulin sensitivity5.
Cholesterol Effects
Two studies showed that consumption of PGX precursor
significantly reduced total and LDL-cholesterol by up to 19%
and 29% in individuals with Metabolic Syndrome or diabetes2,6.
This effect could be compared with the cholesterol lowering
effect of a modest dose of statin drugs. Compared to the
cholesterol lowering effects of major gel-forming fibres
such as psyllium, oats, or guar8, the blend had a
3 to 5 times greater effect, expressed as a change in
cholesterol per gram of consumed soluble fibre5.
Comparable results may be achieved with considerably less
PGX2,6.
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References
- Breitman P, Vuksan V, Lyon M,
"Impact of meal replacement viscosity on appetite and
ad-libitum food consumption in normal weight
adolescents.", Presented at the 8th Annual Canadian
Diabetes Association (CDA)/Canadian Society of
Endocrinology and Metabolism (CSEM) Professional
Conference, October, 2004.
- Vuksan V, Jenkins DJ, Spadafora P,
Sievenpiper JL, Owen R, Vidgen E, Brighenti F, Josse R,
Leiter LA, Bruce-Thompson C, "Konjac-mannan (glucomannan)
improves glycemia and other associated risk factors for
coronary heart disease in type 2 diabetes. A randomized
controlled metabolic trial.", Diabetes Care 22(6):
913-919, 1999.
- Glycemic Index Laboratories,"
Effect of Adding or Incorporating PGX� into
Commonly Consumed Foods on the Glycemic Index.", Winter
Report, January 25, 2007.
- Lyon MR, Reichert RG., "The effect
of a novel polysaccharide blend (PGX™ granules) on
weight loss and other laboratory parameters in mild to
moderately obese adults: an observational retrospective
clinical analysis.", Unpublished.
- Vuksan V, Sievenpiper JL, Xu Z,
Wong EY, Jenkins AL, Beljan-Zdravkovic U, Leiter LA,
Josse RG, Stavro MP., "Konjac-Mannan and American
ginseng: emerging alternative therapies for type 2
diabetes mellitus.", J Am Coll Nutr. 20: 5 Suppl,
370S-380S; discussion 381S-383S, Oct, 2001
- Vuksan V, Sievenpiper JL, Owen R,
Swilley JA, Spadafora P, Jenkins DJ, Vidgen E, Brighenti
F, Josse RG, Leiter LA, Xu Z, Novokmet R., "Beneficial
effects of viscous dietary fibre from Konjac-mannan in
subjects with the insulin resistance syndrome: results
of a controlled metabolic trial.", Diabetes Care 23(1):
9-14, 2000.
- Rogovik A, Jenkins AL, Breitman P,
Vuksan V., "A blend of highly viscous polysaccharides
decreases relative CVD risk in three population
groups.", Presented at Natural Health Product Research
Conference, Toronto, 2006.
Brown L, Rosner B, Willett WW, Sacks FM,
"Cholesterol-lowering effects of dietary fibre: a
meta-analysis.", Am J Clin Nutr. 69(1): 30-42, 1999.
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You deserve to
have your concerns taken seriously. There is so much
bad advice out there. Stop spinning your wheels or
barking up the wrong tree. Try to get to the root of
the problem. You just may find that there is a easier
way to get back to a healthy weight.
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